A single dose of doxycycline in combination with diethylcarbamazine for treatment of bancroftian filariasis.
Identifieur interne : 005A50 ( Main/Exploration ); précédent : 005A49; suivant : 005A51A single dose of doxycycline in combination with diethylcarbamazine for treatment of bancroftian filariasis.
Auteurs : Vivornpun Sanprasert [Thaïlande] ; Anupong Sujariyakul ; Surang NuchprayoonSource :
- The Southeast Asian journal of tropical medicine and public health [ 0125-1562 ] ; 2010.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Association de médicaments, Calendrier d'administration des médicaments, Diéthylcarbamazine (administration et posologie), Diéthylcarbamazine (effets indésirables), Doxycycline (administration et posologie), Doxycycline (effets indésirables), Femelle, Filaricides (administration et posologie), Filaricides (effets indésirables), Filariose lymphatique (traitement médicamenteux), Humains, Jeune adulte, Mâle, Méthode en double aveugle, Wuchereria bancrofti.
- MESH :
- administration et posologie : Diéthylcarbamazine, Doxycycline, Filaricides.
- effets indésirables : Diéthylcarbamazine, Doxycycline, Filaricides.
- traitement médicamenteux : Filariose lymphatique.
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Association de médicaments, Calendrier d'administration des médicaments, Femelle, Humains, Jeune adulte, Mâle, Méthode en double aveugle, Wuchereria bancrofti.
English descriptors
- KwdEn :
- Adolescent, Adult, Animals, Diethylcarbamazine (administration & dosage), Diethylcarbamazine (adverse effects), Double-Blind Method, Doxycycline (administration & dosage), Doxycycline (adverse effects), Drug Administration Schedule, Drug Therapy, Combination, Elephantiasis, Filarial (drug therapy), Female, Filaricides (administration & dosage), Filaricides (adverse effects), Humans, Male, Middle Aged, Wuchereria bancrofti, Young Adult.
- MESH :
- chemical , administration & dosage : Diethylcarbamazine, Doxycycline, Filaricides.
- chemical , adverse effects : Diethylcarbamazine, Doxycycline, Filaricides.
- drug therapy : Elephantiasis, Filarial.
- Adolescent, Adult, Animals, Double-Blind Method, Drug Administration Schedule, Drug Therapy, Combination, Female, Humans, Male, Middle Aged, Wuchereria bancrofti, Young Adult.
Abstract
Standard treatment of lymphatic filariasis with diethylcarbamazine (DEC) is associated with systemic adverse reactions, thought to be due to the release of microfilariae material and Wolbachia endosymbiotic bacteria into the blood. Combination treatments with doxycycline for 3-8 weeks are more effective than standard treatment. However, long-term use of antibiotics may contribute to drug resistance and are not practical for use in remote areas. We assessed whether a single dose of doxycycline combined with the standard DEC regimen would reduce the incidence and severity of adverse reactions and increase the efficacy of standard treatment. Forty-four subjects from Tak Province were recruited into the randomized double-blind clinical trial study: 25 received DEC (300 mg) combined with a placebo, and 19 received DEC (300 mg) combined with doxycycline (200 mg). The incidences of adverse reactions to standard treatment were lower in the doxycycline group (45.5%) than in the placebo group (58.8%). Severe reactions occurred only in the placebo group (3 of 25 subjects). The severity of adverse reactions was significantly lower in the doxycycline group (mean score 0.45) than in the placebo group (mean score 1.17). The levels of IL-6 and Wolbachia DNA in the plasma were significantly lower in the doxycycline group. The filarial antigen levels were significantly lower in the doxycycline group at months 6 after treatment.
PubMed: 21073054
Affiliations:
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Sujariyakul</name></author><author><name sortKey="Nuchprayoon, Surang" sort="Nuchprayoon, Surang" uniqKey="Nuchprayoon S" first="Surang" last="Nuchprayoon">Surang Nuchprayoon</name></author></analytic><series><title level="j">The Southeast Asian journal of tropical medicine and public health</title><idno type="ISSN">0125-1562</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Animals</term><term>Diethylcarbamazine (administration & dosage)</term><term>Diethylcarbamazine (adverse effects)</term><term>Double-Blind Method</term><term>Doxycycline (administration & dosage)</term><term>Doxycycline (adverse effects)</term><term>Drug Administration Schedule</term><term>Drug Therapy, Combination</term><term>Elephantiasis, Filarial (drug therapy)</term><term>Female</term><term>Filaricides (administration & 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qualifier="administration & dosage" xml:lang="en"><term>Diethylcarbamazine</term><term>Doxycycline</term><term>Filaricides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Diethylcarbamazine</term><term>Doxycycline</term><term>Filaricides</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Diéthylcarbamazine</term><term>Doxycycline</term><term>Filaricides</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Diéthylcarbamazine</term><term>Doxycycline</term><term>Filaricides</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Animals</term><term>Double-Blind Method</term><term>Drug Administration Schedule</term><term>Drug Therapy, Combination</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Wuchereria bancrofti</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Association de médicaments</term><term>Calendrier d'administration des médicaments</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Wuchereria bancrofti</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Standard treatment of lymphatic filariasis with diethylcarbamazine (DEC) is associated with systemic adverse reactions, thought to be due to the release of microfilariae material and Wolbachia endosymbiotic bacteria into the blood. Combination treatments with doxycycline for 3-8 weeks are more effective than standard treatment. However, long-term use of antibiotics may contribute to drug resistance and are not practical for use in remote areas. We assessed whether a single dose of doxycycline combined with the standard DEC regimen would reduce the incidence and severity of adverse reactions and increase the efficacy of standard treatment. Forty-four subjects from Tak Province were recruited into the randomized double-blind clinical trial study: 25 received DEC (300 mg) combined with a placebo, and 19 received DEC (300 mg) combined with doxycycline (200 mg). The incidences of adverse reactions to standard treatment were lower in the doxycycline group (45.5%) than in the placebo group (58.8%). Severe reactions occurred only in the placebo group (3 of 25 subjects). The severity of adverse reactions was significantly lower in the doxycycline group (mean score 0.45) than in the placebo group (mean score 1.17). The levels of IL-6 and Wolbachia DNA in the plasma were significantly lower in the doxycycline group. The filarial antigen levels were significantly lower in the doxycycline group at months 6 after treatment.</div></front></TEI><affiliations><list><country><li>Thaïlande</li></country></list><tree><noCountry><name sortKey="Nuchprayoon, Surang" sort="Nuchprayoon, Surang" uniqKey="Nuchprayoon S" first="Surang" last="Nuchprayoon">Surang Nuchprayoon</name><name sortKey="Sujariyakul, Anupong" sort="Sujariyakul, Anupong" uniqKey="Sujariyakul A" first="Anupong" last="Sujariyakul">Anupong Sujariyakul</name></noCountry><country name="Thaïlande"><noRegion><name sortKey="Sanprasert, Vivornpun" sort="Sanprasert, Vivornpun" uniqKey="Sanprasert V" first="Vivornpun" last="Sanprasert">Vivornpun Sanprasert</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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